Publications

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Research

• Vardya, I., Holm, M.M., Dósa, Z., Nieto-Gonzalez, J.L., Nykjær, A., Jensen, K. 2010, 'Increased synaptic GABAergic inhibition in dentate gyrus of mice deficient of sortilin.', presented at Joint meeting of the Scandinavian and German Physiological Societies, Copenhagen, 27.3.2010 - 30.3.2010. Poster accepted
• Tauris, J., Christensen, E.I., Nykjær, A., Jacobsen, C., Petersen, C.M., Ovesen, T. 2009, 'Cubilin and Megalin Co-Localize in the Neonatal Inner Ear', Audiology and Neuro-Otology, vol. 14 no. 4, pp. 267-278.Peer reviewed article
• Holm, M.M., Nieto-Gonzales, J.L., Vardya, I., Vægter, C.B., Nykjær, A., Jensen, K. 2009, 'Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus', Journal of Neuroscience, vol. 29 no. 40, pp. 12412-8.Peer reviewed article
• Gustafsen, C., Tauris, J., Christensen, E.I., Jansen, P., Nykjær, A., Teng, K.K., Schwarz, E., Madsen, P.S., Petersen, C.M. 2009, 'The neurotrophin precursor proNT-3 promotes Sortilin:p75^NTR complex formation and induces apoptosis', presented at Society for Neuroscience 2009, Chicago, 17.10.2009 - 21.10.2009. Poster
• Nielsen, M.S., Keat, S., Hamati, J., Peder, P.S., Gutzmann, J., Engelsberg, A., Pedersen, K., Gustafsen, C., Nykjær, A., Gliemann, J., Hermans-Borgmeyer, I., Petersen, C.M., Hermey, G. 2008, 'Different motifs regulate trafficking of SorCS1 isoforms.', Traffic, vol. 9 no. 6, pp. 980-94.Peer reviewed article
• Willnow, T.E., Hammes, A., Nykjær, A. 2008, 'Endocytosis of sex stereoids: The hypothesis of free hormones revisited.', Annales d'Endocrinologie, vol. 69, pp. 101-2.Peer reviewed article
• Holm, M.M., Nieto-Gonzales, J.L., Vardya, I., Vægter, C.B., Nykjær, A., Jensen, K. 2008, 'Excitability of GABAergic basket cells is regulated by brain derived neurotrophic factor (BDNF), through TrkB, in mouse dentate gyrus', presented at SFN 2008, Washington, 15.11.2008 - 19.11.2008. Poster
• Holm, M.M., Vardya, I., Nieto-Gonzales, J.L., Nykjær, A., Jensen, K. 2008, 'Regulation of GABAergic basket cell excitability by brain derived neurotrophic factor (BDNF) in mouse dentate gyrus', presented at FENS 2008, Poster
• Vægter, C.B., Jansen, P., Erdmann, B., WillNow, T., Lewin, G., Tessarollo, L., Nykjær, A. 2008, 'Sortilin positively modulates survival signaling by mature neurotrophins', presented at Society for Neuroscience 38th Annual Meeting, Washington, 15.11.2008 - 19.11.2008. Poster
• Kjærgaard, M., Skeldal, S., Raarup, M.K., Nykjær, A., Nyengaard, J.R., Nielsen, M.S. Using FRET in the study of the Vps10pD receptors. Annual Meeting of the Nordic Microscopy Society (Scandem). 2008, Other
• Willnow, T.E., Petersen, C.M., Nykjær, A. 2008, 'VPs10p-domain receptors . central regulators of neuronal viability', Nature Reviews Neuroscience, vol. 9, pp. 899-909.Peer reviewed article
• Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E., Nykjaer, A. 2007, 'Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.', Nature Neuroscience, vol. 10 no. 11, pp. 1449-57.Peer reviewed article
• Willnow, T.E., Nykjær, A. 2006, 'Response: cellular uptake of ex steroid hormones', Gekkan Saibo, vol. 124, pp. 456-457.Peer reviewed article
• Hermey, G., Sjøgaard, S., Petersen, C.M., Nykjær, A., Gliemann, J. 2006, 'Tumour necrosis factor-alpha convertase mediates ectodomain shedding of Vps10p-domain receptor family members', Biochem. J., Peer reviewed article in press
• Hermey, G., Sjøgaard, S., Petersen, C.M., Nykjær, A., Gliemann, J. 2006, 'Tumour necrosis factor-α convertase mediates ectodomain shedding of Vps10p-domain receptor family members', Biochem. J., vol. 395 no. 2, pp. 285-293.Peer reviewed article
• Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjær, A., Willnow, T.E. 2005, 'Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein', Proceedings of the National Academy of Science of the United States of America, vol. 102 no. 38, pp. 13461-13466.Peer reviewed article
• Nykjær, A., Willnow, T.E., Pedersen, J.C.M. 2005, 'p75^NTR – To live or let die', Curr. Opin. Neurobiol., vol. 15, pp. 49-57.Review
• Teng, H.K., Teng, K.K., Lee, R., Wright, S., Tevar, S., Almeida, R.D., Kermani, P., Torkin, R., Chen, Z.Y., Lee, F.S., Kraemer, R.T., Nykjær, A., Hempstead, B.L. 2005, 'ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75^NTR and sortilin', Journal of Neuroscience, vol. 25, pp. 5455-5463.Peer reviewed article
• Hammes, A., Andreassen, T.K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F.J., Luppa, P.B., Nykjær, A., Willnow, T.E. 2005, 'Role of endocytosis in cellular uptake of sex steroids', Gekkan Saibo, vol. 122, pp. 751-762.Peer reviewed article
• Chen, Z.Y., Ieraci, A., Teng, H.K., Dall, H., Meng, C.X., Herrera, D.G., Nykjær, A., Hempstead, B.L., Lee, F.S. 2005, 'Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway', Journal of Neuroscience, vol. 25, pp. 6155-6166.Peer reviewed article
• Willnow, T.E., Nykjær, A. 2004, 'Endocytic Pathways for 25-(OH) Vitamin D3', Elsevier Academic Press, pp. 153-166.Review
• Westergaard, U.B., Sørensen, E.S., Hermey, G., Nielsen, M.S., Nykjær, A., Kirkegaard, K., Jacobsen, C., Gliemann, J., Madsen, P.S., Pedersen, J.C.M. 2004, 'Functional organization of the sortilin Vps10p domain', Journal of Biological Chemistry, vol. 279, pp. 50221-50229.Peer reviewed article
• Nykjær, A., Lee, R., Teng, K.K., Jansen, P., Madsen, P.S., Nielsen, M.S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T.E., Hempstead, B.L., Pedersen, J.C.M. 2004, 'Sortilin is essential for proNGF-induced neuronal cell death', Nature, vol. 427, pp. 843-848.Peer reviewed article
• Gliemann, J., Hermey, G., Nykjær, A., Petersen, C.M., Jacobsen, C., Andreasen, P. 2004, 'The mosaic receptor sorLA/LR11 binds components of the plasminogen activating system and PDGF-BB similarity to low density lipoprotein receptor-related protein (LRP1) but mediates slow internalization of bound', Biochem. J., vol. 381, pp. 203-212.Peer reviewed article
• Gliemann, J., Hermey, G., Nykjær, A., Pedersen, J.C.M., Jacobsen, C., Andreasen, P.A. 2004, 'The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.', Biochem. J., vol. 381, pp. 203-212.Peer reviewed article
• Muller, D., Nykjær, A., Willnow, T.E. 2003, 'From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia', Ann Med, no. 35, pp. 290-299.Review
• Leheste, J.R., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner-Muller, I., Andreassen, T.T., Wolf, E., Bachmann, S., Nykjær, A., Willnow, T.E. 2003, 'Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect', The FASEB Journal, no. 17, pp. 247-249.Article
• Hilpert, J., Wogensen, L., Thykjaer, T., Wellner, M., Schlichting, U., Ørntoft, T.F., Bachmann, S., Nykjær, A., Willnow, T.E. 2002, 'Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism', Kidney International, vol. 62 no. 5, pp. 1672-1681.Article
• Willnow, T.E., Nykjær, A. 2002, 'Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3', Curr Opin Lipidol, vol. 13 no. 3, pp. 255-260.Review
• Nykjær, A., Willnow, T.E. 2002, 'The low-density lipoprotein receptor gene family: a cellular Swiss army knife?', Trends Cell Biol., vol. 12 no. 6, pp. 273-280.Review
• Burmeister, R., Boe, I.M., Nykjær, A., Jacobsen, C., Moestrup, S.K., Verroust, P., Christensen, E.I., Lund, J., Willnow, T.E. 2001, 'A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney', Journal of Biological Chemistry, vol. 276, pp. 13295-13301.Peer reviewed article
• Nykjær, A., Fyfe, J.C., Kozyraki, R., Leheste, J.R., Jacobsen, C., Nielsen, M.S., Verroust, P.J., Aminoff, M., de la Chapelle, A., Moestrup, S.K., Ray, R., Gliemann, J., Willnow, T.E., Christensen, E.I. 2001, 'Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)', Proceedings of the National Academy of Science of the United States of America, vol. 98, pp. 13895-13900.Peer reviewed article
• Hilpert, J., Vorum, H., Burmeister, R., Spoelgen, R., Grishkovskaya, I., Misselwitz, R., Nykjær, A., Willnow, T.E. 2001, 'Efficient eukaryotic expression system for authentic human sex hormone-binding globulin', Biochem. J., vol. 360, pp. 609-615.Article
• Nielsen, M.S., Madsen, P.S., Christensen, E.I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R., Pedersen, J.C.M. 2001, 'The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein', EMBO Journal, vol. 20, pp. 2180-2190.Article
• Nykjær, A., Dragun, D., Walther, D., Vorum, H., Christian, C., Herz, J., Melsen, F., Christensen, E.I., Willnow, T.E. 1999, 'An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D₃ ', Gekkan Saibo, vol. 96, pp. 507-515.Peer reviewed article
• Christensen, E.I., Moskaug, J.Ø., Vorum, H., Jacobsen, C., Gundersen, T.E., Nykjær, A., Blomhoff, R., Willnow, T.E., Moestrup, S.K. 1999, 'Evidence for an essential role of megalin in transepithelial transport of retinol', Journal of the American Society of Nephrology, vol. 10, pp. 685-695.Peer reviewed article
• Hilpert, J., Nykjær, A., Jacobsen, C., Wallukat, G., Nielsen, R., Moestrup, S.K., Haller, H., Luft, F.C., Christensen, E.I., Willnow, T.E. 1999, 'Megalin antagonizes activation of the parathyroid hormone receptor', Journal of Biological Chemistry, vol. 274, pp. 5620-5625.Peer reviewed article
• Leheste, J.-R., Rolinski, B., Vorum, H., Hilpert, J., Nykjær, A., Jacobsen, C., Aucouturier, P., Moskaug, J.Ø., Otto, A., Christensen, E.I., Willnow, T.E. 1999, 'Megalin knockout mice as an animal model of low molecular weight proteinuria', American Journal of Pathology, vol. 155, pp. 1361-1370.Peer reviewed article
• Nykjær, A., Christensen, E.I., Vorum, H., Hager, H., Petersen, C.M., Røigaard, H., Min, H.Y., Vilhardt, F., Møller, L.B., Kornfeld, S., Gliemann, J. 1998, 'The 275 kDa cation-independent mannose-6-phosphate receptor targets the urokinase receptor to lysosomes via a novel binding interaction', J. Cell. Biol., vol. 141, pp. 815-828.Peer reviewed article
• Petersen, C.M., Nielsen, M.S., Nykjær, A., Jacobsen, L., Tommerup, N., Rasmussen, H., Røigaard, H., Gliemann, J., Peder, P.S., Moestrup, S.K. 1997, 'Molecular identification of anovel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography', Journal of Biological Chemistry, vol. 272, pp. 3599-3605.Peer reviewed article
• Nykjær, A., Conese, M., Christensen, E.I., Olson, D., Cremona, O., Gliemann, J., Blasi, F. 1997, 'Recycling of the urokinase receptor upon internalization of the uPA:Serpin complexes', EMBO Journal, vol. 16, pp. 2610-2620.Peer reviewed article
• Petersen, C.M., Ellgaard, L., Nykjær, A., Vilhardt, F., Vorum, H., Thøgersen, H.C., Nielsen, M.S., Jacobsen, C., Moestrup, S.K., Gliemann, J. 1996, 'The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II', EMBO Journal, vol. 15 no. 16, pp. 4165-4173.Peer reviewed article
• Conese, M., Nykjær, A., Petersen, C.M., Cremona, O., Pardi, R., Andreasen, P.A., Gliemann, J., Christensen, E.I., Blasi, F. 1995, 'Alpha-2 macroglobulin receptor/LDL receptor-related protein (LRP)-dependent internalization of the urokinase receptor', J. Cell. Biol., vol. 131, pp. 1609-1622.Peer reviewed article
• Nielsen, M.S., Nykjær, A., Warshawsky, I., Schwartz, A.L., Gliemann, J. 1995, 'Analysis of ligand binding to the α2-macroglobulin receptor/low density lipoprotein receptor-related protein', Journal of Biological Chemistry, vol. 270, pp. 23713-23719.Peer reviewed article
• Cavallaro, U., Nykjær, A., Nielsen, M.S., Soria, M.R. 1995, 'α2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins', European Journal of Biochemistry, vol. 232, pp. 165-171.Peer reviewed article
• Nykjær, A., Nielsen, M.S., Meyer, M., Røigaard, H., Etzerodt, M., Lookene, A., Beisiegel, U., Olivecrona, G., Gliemann, J. 1994, 'A C-terminal fragment of lipoprotein lipase binds to LDL receptor-related protein and inhibits lipase-mediated uptake of β-VLDL lipoprotien particles', Journal of Biological Chemistry, vol. 267, pp. 31747-31755.Peer reviewed article
• Gliemann, J., Nykjær, A., Petersen, C.M., Jørgensen, K.E., Andreasen, P., Christensen, E.I., Moestrup, S.K. 1994, 'The multiligand α₂-macroglobulin receptor/low density lipoprotein receptor-related protein', Ann. N. Y. Acad. Sci., vol. 737, pp. 20-38.Review
• Gliemann, J., Nykjær, A., Petersen, C.M., Jørgensen, K.E., Nielsen, M.S., Andreasen, P., Christensen, E.I., Lookene, A., Olivecrona, G., Moestrup, S.K. 1994, 'The α2-macroglobulin receptor/low density lipoprotein receptor-related protein. Binding and endocytosis of fluid-phase and membrane-associated ligands', Ann. N. Y. Acad. Sci., vol. 737, pp. 20-38.Peer reviewed article
• Moestrup, S.K., Holtet, T.L., Etzerodt, M., Thøgersen, H.C., Nykjær, A., Andreasen, P., Rasmussen, H.H., Sottrup-Jensen, L., Gliemann, J. 1993, 'Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha(2)-Macroglobulin receptor containing a cluster of eight complement-type repeats', Journal of Biological Chemistry, vol. 268 no. 18, pp. 13691-13696.Peer reviewed article
• Moestrup, S.K., Nielsen, S., Jørgensen, K.E., Nykjær, A., Andreasen, P., Røigaard, H., Gliemann, J., Christensen, E.I. 1993, 'Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activiator inhibitor type-1 complexes', Journal of Biological Chemistry, vol. 268, pp. 16564-16570.Peer reviewed article
• Nykjær, A., Petersen, C.M., Møller, B., Jensen, P.H., Moestrup, S.K., Holtet, T.L., Etzerodt, M., Thøgersen, H.C., Munch, M., Andreasen, P., Gliemann, J. 1992, 'Purified alpha(2)-Macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha(2)-Macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes', Journal of Biological Chemistry, vol. 267 no. 21, pp. 14543-14546.Peer reviewed article

Please note: The registration of research publications may be incomplete for publications prior to 2001, when ongoing registration was initiated. The registration of research communication was begun in 2005. A number of researchers have registered publications previously issued.

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